PAN-ANCA(TM) EVALUATION
Marquette General Health System

General Info

Alpha Code

  ANCA

MGH LIS Test No

  550

Schedule

  Monday-Saturday

Testing Time

  Negative - 1-2 days / Positive - 2-3 days

Testing Lab

  Specialty Labs, Inc.

QORR Test Code

  ANCA

Specimen Info

Type

  Serum  

Volume

  2.0 (1.0) mL

Temperature

  Frozen

Preservative

   

Collection Info

   
 
Specimen Acceptability

Methods
ANCA performed by Image Analysis and reflexed to IFA.

Clinical Utilities
Antineutrophil cytoplasmic autoantibodies (ANCA) are a serological marker associated with vasculitis and glomerulonephritis. Specifically, ANCA have been found (at frequencies ranging from 70% to 90%) in patients with active Wegener's granulomatosis, microscopic polyarteritis nodosa, and idiopathic crescentic glomerulonephritis (with manifestations ranging from kidney-limited disease to extrarenal systemic disease, including pulmonary-renal syndromes). Glomerular lesions in patients with ANCA-associated systemic vasculitis or renal- limited disease are virtually identical. Normal controls are negative for ANCA and <10% of patients with other renal diseases are positive. ANCA may be directly involved in the pathogenesis of the vascular injury that causes the clinical manifestations in ANCA-associated disease.

CPT Codes
86038, 86021x3

Reference Range

Component Information

Name

  ANCA TOTAL ANTIBODIES 

Method

  IFA 

CPT Code

  86021 

Units

  <1:20 FIU 
Ref Range    
Reflex Reason    
     

Name

  ANCA PATTERN 

Method

  IFA 

CPT Code

  83520 

Units

   
Ref Range   Not Detected 
Reflex Reason    
     

Name

  PROTEINASE-3 AUTOANTIBODIES 

Method

  EIA 

CPT Code

  83520 

Units

  <3.5 U/mL 
Ref Range    
Reflex Reason    
     

Name

  ANTINUCLEAR ANTIBODIES (ANA) 

Method

  IFA/IMAGE 

CPT Code

  86038 

Units

  IFA/IMAGE 
Ref Range   Less than 7.5 
Reflex Reason    
     

Name

  ANA PATTERN 

Method

  IFA 

CPT Code

   

Units

  IFA 
Ref Range    
Reflex Reason    
     

Name

  MYELOPEROXIDASE AUTOANTIOBODIES 

Method

  EIA 

CPT Code

  86021 

Units

  <9.0 U/mL 
Ref Range    
Reflex Reason    
     
Collection Notes

Additional Comments
Specialty recommends simultaneous testing for Glomerular Basement Membrane IgG Autoabs, #1136 if clinically indicated. See PAN-ANCA(tm) PLUS, #1868, the method of choice for ANCA. See also Rapidly Progressive Glomerulonephritis Evaluation, #1726.

 

Questions or Comments email support@mgh.org

Reference Lab Home Page
Laboratory Main Page
Marquette General Health System Home Page