Clinical Utilities
Antineutrophil cytoplasmic autoantibodies (ANCA) are a serological marker associated with vasculitis and glomerulonephritis. Specifically, ANCA have been found (at frequencies ranging from 70% to 90%) in patients with active Wegener's granulomatosis, microscopic polyarteritis nodosa, and idiopathic crescentic glomerulonephritis (with manifestations ranging from kidney-limited disease to extrarenal systemic disease, including pulmonary-renal syndromes). Glomerular lesions in patients with ANCA-associated systemic vasculitis or renal- limited disease are virtually identical. Normal controls are negative for ANCA and <10% of patients with other renal diseases are positive. ANCA may be directly involved in the pathogenesis of the vascular injury that causes the clinical manifestations in ANCA-associated disease.

CPT Codes
86038, 86021x3

Reference Range

Component Information

Name		ANCA TOTAL ANTIBODIES
Method		IFA
CPT Code		86021
Units		<1:20 FIU
Ref Range
Reflex Reason

Name		ANCA PATTERN
Method		IFA
CPT Code		83520
Units
Ref Range		Not Detected
Reflex Reason

Name		PROTEINASE-3 AUTOANTIBODIES
Method		EIA
CPT Code		83520
Units		<3.5 U/mL
Ref Range
Reflex Reason

Name		ANTINUCLEAR ANTIBODIES (ANA)
Method		IFA/IMAGE
CPT Code		86038
Units		IFA/IMAGE
Ref Range		Less than 7.5
Reflex Reason

Name		ANA PATTERN
Method		IFA
CPT Code
Units		IFA
Ref Range
Reflex Reason

Name		MYELOPEROXIDASE AUTOANTIOBODIES
Method		EIA
CPT Code		86021
Units		<9.0 U/mL
Ref Range
Reflex Reason

Collection Notes

Additional Comments
Specialty recommends simultaneous testing for Glomerular Basement Membrane IgG Autoabs, #1136 if clinically indicated. See PAN-ANCA(tm) PLUS, #1868, the method of choice for ANCA. See also Rapidly Progressive Glomerulonephritis Evaluation, #1726.