FISH ANALYSIS FIP1L1-PDGFRA, CHIC2
Marquette General Health System

General Info

HLAB/HOL Code

  CYTOGNREQ

MGH LIS Test No

  2514

Schedule

  Monday-Friday

Testing Time

  1-3 Days

Testing Lab

  Marquette General Hospital

QORR Test Code

  CYTOGNREQ

Specimen Info

Type

  Bone Marrow or Malignant Blood  

Volume

  3.0 mL Bone Marrow or 5.0 mL Blood

Temperature

  Ambient

Preservative

   

Collection Info

  Bone Marrow is the tissue of choice for 
initial diagnosis of most neoplastic 
specimens.  Malignant blood can be 
used in certain cases to monitor minimal
residual disease.

Prefer a minimum of 3.0 mL of bone marrow 
or 5.0 mL of malignant blood.  Draw into 
green-top (sodium heparin) tube(s), invert 
several times to mix (clotted specimens 
may not work and can compromise results).  
Label vial with the patient's name and a 
unique identifying number (MGHS encounter #
 or MR #).  Maximum time from 
collection should be 24 hours.

SPECIMENS CANNOT BE FROZEN
 
Specimen Acceptability

Methods
Interphase set-up and analysis. A minimum of 200 interphase nuclei will be analyzed.

Clinical Utilities
Detection of the Fip 1-like1 (FIP1L1) and platelet derived growth factor receptor alpha gene product associated with chronic hypereosinophilia with systemic mast cell disease. The FIP1L1 and PDGFR alpha fusion is a known target for imatinib mesylate therapy.

CPT Codes
88271x3, 88275x1, 88291, 88237 (as needed, at additional charge)

The CPT codes provided are based on AMA guidelines
and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions
regarding coding to the payer being billed.

Reference Range
An interpretive report will be provided.

Component Information

Collection Notes

Additional Comments

 

Questions or Comments email support@mgh.org

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