FISH ANALYSIS HER-2/NEU (PATHVYSION TM HER-2)
Marquette General Health System
HLAB/HOL Code |
CYTOGNREQ | |
MGH LIS Test No |
4764 | |
Schedule |
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Testing Time |
2-8 Days | |
Testing Lab |
Marquette General Hospital | |
QORR Test Code |
CYTOGNREQ | |
Type |
Paraffin-embedded Tumor Tissue | |
Volume |
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Temperature |
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Preservative |
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Collection Info |
Specimen must be fixed in 10% neutral buffered formalin fixed paraffin-embedded breast cancer block. Optimum fixation time 12-24 hrs but not to exceed 48 hrs or be less than 6 hrs. Maintain the specimen at room temperature. Do not Freeze. Please Provide: (1) Pathology Reprot (2) H & E of the fixed specimen. Region of invasive carcinoma marked by a pathologist on the H & E. Limitations or Unacceptable Conditions: Tissue not verified for presence of invasive carcinoma. Specimen fixed in fixative other than 10% neutral buffered formalin. Intended for grade III/III DCIS and not grades I & II. |
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Clinical Utilities
Detection of amplification of the HER2 gene associated
with invasive breast cancer. The detection of the presence
of HER-2 gene amplification is based on counting
fluorescent HER-2/neu signals and CEP 17 signals contained
within the 60 interphase nuclei of invasive carcinoma
cells. HER-2/nue FISH detection is indicated as an aid in the
assessment of patients for whom HERCEPTIN (Trastuzumab)
treatment is being considered.
CPT Codes
88274 x 1 Hybridization 25-99 cells
88271x2 DNA probe; each
88291x1 Interpretation and Reporting
The CPT codes provided are based on AMA guidelines
and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions
regarding coding to the payer being billed.
Reference Range
An interpretive report will be provided.
Component Information
Additional Comments Questions or Comments email support@mgh.org
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