FISH ANALYSIS HER-2/NEU (PATHVYSION TM HER-2)
Marquette General Health System
HLAB/HOL Code |
CYTOGNREQ | |
MGH LIS Test No |
4764 | |
Schedule |
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Testing Time |
2-8 Days | |
Testing Lab |
Marquette General Hospital | |
QORR Test Code |
CYTOGNREQ | |
Type |
Paraffin-embedded Tumor Tissue | |
Volume |
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Temperature |
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Preservative |
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Collection Info |
Specimen must be fixed in 10% neutral buffered formalin fixed paraffin-embedded breast cancer block. Optimum fixation time 12-24 hrs but not to exceed 48 hrs or be less than 6 hrs. Maintain the specimen at room temperature. Do not Freeze. Please Provide: (1) Pathology Reprot (2) H & E of the fixed specimen. Region of invasive carcinoma marked by a pathologist on the H & E. Limitations or Unacceptable Conditions: Tissue not verified for presence of invasive carcinoma. Specimen fixed in fixative other than 10% neutral buffered formalin. Intended for grade III/III DCIS and not grades I & II. |
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Clinical Utilities
Detection of amplification of the HER2 gene associated
with invasive breast cancer. The detection of the presence
of HER-2 gene amplification is based on counting
fluorescent HER-2/neu signals and CEP 17 signals contained
within the 60 interphase nuclei of invasive carcinoma
cells. HER-2/nue FISH detection is indicated as an aid in the
assessment of patients for whom HERCEPTIN (Trastuzumab)
treatment is being considered.
CPT Codes
88274 x 1 Hybridization 25-99 cells
88271x2 DNA probe; each
88291x1 Interpretation and Reporting
Reference Range
An interpretive report will be provided.
Component Information
Additional Comments Questions or Comments email support@mgh.org
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