FISH ANALYSIS RB1/13Q34
Marquette General Health System

General Info

HLAB/HOL Code

  CYTOGNREQ

MGH LIS Test No

  1454

Schedule

  Monday-Friday

Testing Time

  1-2 Days

Testing Lab

  Marquette General Hospital

QORR Test Code

  CYTOGNREQ

Specimen Info

Type

  Bone Marrow or Malignant Blood  

Volume

  3.0 mL Bone Marrow or 5.0 mL Blood

Temperature

  Ambient

Preservative

   

Collection Info

  Bone Marrow is the tissue of choice for 
initial diagnosis of most neoplastic 
specimens.  Malignant blood can be 
used in certain cases to monitor minimal
residual disease.

Prefer a minimum of 3.0 mL of bone marrow
or 5.0 mL of malignant blood.  Draw into 
green-top (sodium heparin) tube(s), invert 
several times to mix (clotted specimens 
may not work and can compromise results).  
Label vial with the patient's name and a 
unique identifying number (MGHS encounter #
 or MR #).  Maximum time from 
collection should be 24 hours.

SPECIMENS CANNOT BE FROZEN
 
Specimen Acceptability

Methods
Interphase set-up and analysis. A minimum of 200 inerphase nuclei will be analyzed.

Clinical Utilities
Diagnosis of loss of RB1 gene located on chromosome 13 at q14. Loss of RB1 indicating 13q deletion or monosomy 13 can be found in many disorders such as multiple myeloma, chronic lymphocytic leukemia, and myelodisplasia.

CPT Codes
88271x2 DNA Probe, Each 88275 - Interphase in situ Hybridization 88291 - Interpretation and Reporting As needed, at additional charge: 88237- Cell Culture-Lymphocytes

The CPT codes provided are based on AMA guidelines
and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions
regarding coding to the payer being billed.

Reference Range
An interpretive report will be provided.

Component Information

Collection Notes

Additional Comments

 

Questions or Comments email support@mgh.org

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