FISH ANALYSIS IGH/BCL2
Marquette General Health System

General Info

Alpha Code

  CYTOGNREQ

MGH LIS Test No

   

Schedule

  Monday-Friday

Testing Time

  1-2 Days

Testing Lab

  Marquette General Hospital

QORR Test Code

  FISHIG

Specimen Info

Type

  Bone Marrow or Malignant Blood  

Volume

  3.0 mL Bone Marrow or 5.0 mL Blood

Temperature

  Ambient

Preservative

   

Collection Info

  Bone Marrow is the tissue of choice for 
initial diagnosis of most neoplastic 
specimens.  Malignant blood can be 
used in certain cases to monitor minimal
residual disease.

Prefer a minimum of 3.0 mL of bone marrow
or 5.0 mL of malignant blood.  Draw into 
green-top (sodium heparin) tube(s), invert 
several times to mix (clotted specimens 
may not work and can compromise results).  
Label vial with the patient's name and a 
unique identifying number (MGHS encounter #
 or MR #).  Maximum time from 
collection should be 24 hours.

SPECIMENS CANNOT BE FROZEN
 
Specimen Acceptability

Methods
Interphase set-up and analysis. A minimum of 500 interphase nuclei will be analyzed.

Clinical Utilities
Diagnosis of BCL2-IGH gene fusion associated with t(14;8)(q32;q21) characteristic of follicular cell lymphoma.

CPT Codes
88271x2 (DNA probe, each), 88275x2 (Interphase in situ hybridization), 88291 (Interpretation and reporting). The following CPT codes are added at additional charge as needed: 88230 (Cell culture, lymphocytes).

Reference Range
0-0.6% fusion = Normal
Above 0.6% fusion  Abnormal

Component Information

Collection Notes

Additional Comments

 

Questions or Comments email support@mgh.org

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