CHROMOSOME ANALYSIS, HIGH RESOLUTION, BLOOD
Marquette General Health System

General Info

HLAB/HOL Code

   CYTOGNREQ

MGH LIS Test No

    

Schedule

   Monday-Friday

Testing Time

   7-9 Days

Testing Lab

   Marquette General Hospital

QORR Test Code

   MISC

Specimen Info

Type

   1 Green Top (Sodium Heparin)  

Volume

   5.0 mL Whole Blood

Temperature

   Ambient

Preservative

    

Collection Info

   Draw a minimum of 5.0 mL of blood into 
green-top (sodium heparin) tube(s), invert 
several times to mix  (clotted blood will 
not work.)  Other anticoagulants may be
harmful to the viability of the cells.  Label
 vial with patient's name and a unique 
identifying number (MGHS encounter # 
or MR #).  Maximum time from collection 
should be 48 hours.

SPECIMENS CANNOT BE FROZEN
 
Specimen Acceptability

Methods
Includes GTG banding, 20 metaphases counted, 5 analyzed, and 3 karyogrammed, including at least one metaphase of representative length and banding for the case. High-resolution band length should be equal to or greater than 600 bands, and must be not less than 550 bands. 600 bands is the preferred reporting level. Further studies, including FISH techniques, may be necessary.

Clinical Utilities
High-resolution chromosome analysis is useful in detecitng small chromosome abnormalities undectable by routine methods and precisely identifying chromosome abnormalities previously detected by routine methods. It is strongly recommended for all congenital anomalies, mental retardation (MR), growth retardation, developmental delay (DD), dysmorphic features, phenotype suggestive of microdeletion syndromes, positive family history of abnormal pregnancy outcome, and autistic spectrum disorders (ASD).

CPT Codes
88230 (Tissue culture lymphocyte), 88262 (Chromosome analysis 15-20 cells), 88289 (Chromosome analysis, additional high resolution study), 88291 (Interpretation and reporting). The following CPT codes are added as needed at additional charge: 88280 (additional karyotypes), 88285 (additional cells), 88261 (STAT analysis; 5 cells and 1 karyotype).

The CPT codes provided are based on AMA guidelines
and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions
regarding coding to the payer being billed.

Reference Range
46,XX or 46,XY.  No apparent abnormality.

Component Information

Collection Notes

Additional Comments

 

Questions or Comments email support@mgh.org

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