CHROMOSOME ANALYSIS, CONGENITAL, BLOOD
Marquette General Health System

General Info

Alpha Code

   CYTOGNREQ

MGH LIS Test No

    

Schedule

   Monday-Friday

Testing Time

   6-8 Days

Testing Lab

   Marquette General Hospital

QORR Test Code

   CHRCG

Specimen Info

Type

   1 Green Top (Sodium Heparin)  

Volume

   5.0 mL Whole Blood

Temperature

   Ambient

Preservative

    

Collection Info

   Prefer a minimum volume of 5.0 mL of blood.  
Draw into green-top (sodium heparin) 
tube(s), invert several times to mix 
(clotted blood will not work).  Other 
anticoagulants may be harmful to the 
viability of the cells.  Label vial with patient's 
name and a unique identifying number 
(MGHS encounter #, MR#).  Maximum time 
from collection should be 48 hours.

SPECIMENS CANNOT BE FROZEN.
 
Specimen Acceptability

Methods
Includes GTG banding, 20 metaphases, 5 analyzed, and 2 karyogrammed, including at least one metaphase of representative length and banding for the case. Standard analysis must be at least 550 bands. Further studies, inlcuding FISH techniques, may be necessary.

Clinical Utilities
Routine peripheral blood chromosome analysis can be useful in the following instances: sexual ambiguity, mosaic studies, multiple miscarriages, and infertility. Please order high resolution analysis (see Chromosome Analysis, High Resolution, Blood) for the following conditions: congenital anomalies, mental retardation(MR), growth retardation, developmental delay (DD), dysmorphic features, phenotype suggestive of microdeletion syndromes, positive family history of abnormal pregnancy outcome, and autisitic spectrum disorders (ASD). Mosaic Studies: Please indicate mosaic study when necessary (eg. Turner syndrome). If possible, specify the number of additional cells to be counted. Additional charges may apply.

CPT Codes
88230 (tissue culture, lymphocyte), 88262 (chromosome analysis, 15-20 cells), 88291 (interpretation and report). In addition the following CPT codes may be added as needed: 88280 (additional karyotypes), 88285 (additional cells), 88261 (STAT analysis; 5 cells and 1 karyotype).

Reference Range
46,XX, or 46,XY.  No apparent abnormality.

Component Information

Collection Notes

Additional Comments

 

Questions or Comments email support@mgh.org

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