CHROMOSOME ANALYSIS, HEMATOLOGIC, BONE MARROW
Marquette General Health System

General Info

HLAB/HOL Code

   CYTOGNREQ

MGH LIS Test No

    

Schedule

   Monday-Friday

Testing Time

   5-7 Days

Testing Lab

   Marquette General Hospital

QORR Test Code

   CHRBM

Specimen Info

Type

   1 Green Top (Sodium Heparin)  

Volume

   3.0 mL of Bone Marrow

Temperature

   Ambient

Preservative

    

Collection Info

   Note:  Bone Marrow is the tissue
 of choice for initial diagnosis of 
most neoplastic specimens.  For 
malignant whole blood testing 
information please see " Chromosome 
Analysis, Hematologic, Blood" in the 
test directory.  Studies on malignant 
blood can be informative in advanced 
stages of disease where abnormal cells 
have infiltrated to peripheral blood. 
Generally, chromosome analysis will 
be successful if greater than 10 % 
blasts are present.

Procure a minimum of 3.0 mL of Bone 
Marrow in a green-top (sodium heparin) 
tube(s), invert several times to mix. 
Clotted specimens may not work and 
can compromise results.  Other 
anticoagulants may be harmful to the 
viability of the cells.  Label vial with 
patient's name and a unique identifying 
number (MGHS encounter #, or MR#).  
Maximum time from collection should 
be 24 hours.

SPECIMENS CANNOT BE FROZEN.
 
Specimen Acceptability

Methods
Includes GTG banding, analysis of 20 or more metaphases, and karyograms for each cell line. Further studies, including FISH techniques, may be necessary.

Clinical Utilities
Chromosome analysis is useful for the diagnosis and classification of certain malignant hematological disorders, evaluating the prognosis in patients with certain malignant hematological disorders, monitoring the effects of treatment, and monitoring patients in remission.

CPT Codes
88237(tissue culture), 88264(chromosome analysis, 20-25 cells), 88291(Report and Interpretation). The following CPT codes may be added at additional charge if needed: 88280 (additional karyotypes), 88285 (additional cells), 88261 (STAT analysis; 5 cells and 1 karyotype).

The CPT codes provided are based on AMA guidelines
and are for informational purposes only. CPT coding is the
sole responsibility of the billing party. Please direct any questions
regarding coding to the payer being billed.

Reference Range
46,XX or 46,XY.  No apparent abnormality.

Component Information

Collection Notes

Additional Comments

 

Questions or Comments email support@mgh.org

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