QUAD SCREEN (SECOND TRIMESTER) MATERNAL, SERUM
Marquette General Health System

General Info

Alpha Code

   QDSCN

MGH LIS Test No

   562

Schedule

   Monday through Friday, Saturday

Testing Time

   1 day from arrival at Mayo Lab

Testing Lab

   Mayo Labs

QORR Test Code

   QDSCN

Specimen Info

Type

   Red Top or SST  

Volume

   1.0 mL of Serum

Temperature

   Refrigerated

Preservative

    

Collection Info

    Draw blood in a plain, red-top tube(s) or a serum gel tube(s). 
Spin down immediately and send 1.0 mL of maternal serum
refrigerated.
Note:    1. The following information is required for processing:
            A.   Maternal date of birth (not age), weight, race,
                   and number of fetuses.
           Note:  Clinical interpretation is not possible if 
                     3 or more fetuses are present or in twin pregnancies 
                     with a insulin-dependent diabetic mother.
            B.      Is patient an insulin-dependent diabetic? 
            C.   Gestational age calculation 
                  (Provide at least 1 of the following):
                    1.  Date of ultrasound and gestation by
                         ultrasound on the date ultrasound was 
                         performed. 

                    Note:    Do not extrapolate to draw date.
                                Twin pregnancies must have 
                                ultrasound information included.

                              2.  First day of last menstrual period (LMP)
                              3.  Gestation by physical exam
                              4.  Expected date of delivery, must specify 
                                   by LMP or ultrasound. 

                       D.   In vitro fertilization pregnancy-
                             Please provide donor date of 
                             birth as this may have a significant 
                             impact on calculated screen risk. 

             2.  Gestational age must be between 15 and 22 weeks for neural 

                       tube interpretation; 16 to 18 weeks is optimal. Down 

                       syndrome and trisomy 18 risk interpretation is 
                       provided between 14 and 22 weeks.

                  3.  Please include coompleted AFP4 form.
                  4.  If this is a repeat analysis, please note previous 
                       laboratory control number.
 
Specimen Acceptability

Methods
Two-site Immunoenzymatic (sandwich) assay, ELISA

Clinical Utilities

CPT Codes
82105, 82677, 84702 X2, 86336.

Reference Range
Neural Tube Defects
An AFP multiple of the median (MoM) <2.5 is reported as screen
negative.  AFP MoM >or=2.5 (singleton pregnancies) and >
 or= 5.33 (twin gestation) are reported as screen positive.

Down Syndrome
Calculated screen risks <1270 are reported as screen negative, risks
1/270 are reported as screen positive.

Trisomy 18
Calculated risks <1/100 are reported as screen negative, risks 1/100 are reproted
as screen positive.

An interpretive report will be provided.

Component Information

Collection Notes

Additional Comments

 

Questions or Comments email support@mgh.org

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