CARBAMAZEPINE-10,11-EPOXIDE, PLASMA

CARBAMAZEPINE-10,11-EPOXIDE, PLASMA
Marquette General Health System

General Info

Alpha Code		C8064
MGH LIS Test No		8064
Schedule		Monday through Saturday
Testing Time		1 day
Testing Lab		Mayo Labs
QORR Test Code		C8064

Specimen Info

Type		1 Lavender Top
Volume		2.0 mL EDTA plasma
Temperature		Refrigerate
Preservative
Collection Info		Draw blood in a lavender-top (EDTA) tube(s) 12 hours (trough value) after last dose. Spin down and send 2.0 mL of EDTA plasma refrigerated.

Specimen Acceptability

Methods
High-Performance Liquid Chromatography (HPLC) Enzyme-Multiplied Immunoassay Technique (EMIT) Includes Carbamazepine. Useful for monitoring patients exhibiting symptoms of carbamazepine toxicity whose serum carbamazepine concentration is within the therapeutic range but who may be producing significant levels of the active metabolite epoxide.
Clinical Utilities
CPT Codes
80156/carbamazepine 80299/carbamazepine-10,11-Epoxide
Reference Range
CARBAMAZEPINE
  Therapeutic concentration:  2-10 ug/mL
  Toxic concentration (automatic call-back):  > or = 12 ug/mL
CARBAMAZEPINE-10,11-EPOXIDE
  Therapeutic concentration:  0.4-4.0 ug/mL
  Toxic concentration (automatic call-back): > or = 8.0 ug/mL
Component Information
Collection Notes
Additional Comments

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