COPPER, LIVER TISSUE
Marquette General Health System

General Info

Alpha Code

  C8034

MGH LIS Test No

  8034

Schedule

  Monday through Saturday

Testing Time

  2 days

Testing Lab

  Mayo Labs

QORR Test Code

  C8034

Specimen Info

Type

     

Volume

   

Temperature

  Refrig\Ambient or Frozen OK

Preservative

   

Collection Info

  1. 0.5 mm x 1.0 cm from a needle biopsy of the liver; a larger section
   is needed from a wedge biopsy.
2. Send in Mayo metal-free specimen vial (blue label) supplied by
   Mayo Medical Laboratories.
3. Any specimen vial other than a Mayo metal-free vial used should
   be plastic, leached with 10% nitric acid for 2 days, rinsed
   with redistilled water, and dried in clean air.
4. Send specimen refrigerated (keep specimen cool with frozen coolant
   April-October, refrigerated coolant November-March).
5. Paraffin block is also acceptable.
NOTE:  Include suspected diagnosis and clinical information.      
 
Specimen Acceptability

Methods
Inductively Coupled Plasma-Mass Spectrometer If specimen is other than liver tissue, see "Miscellaneous Metals."

Clinical Utilities

CPT Codes
82525

Reference Range
10-35 ug/g dry weight      

Result Interpretation

35-250 UG/G Dry Weight.........High.  Excessive copper at 
this level can be associated with cholestatic liver disease,
such as primary biliary cirrhosis,primary sclerosing cholangitis,
autoimmune hepatitis, and familial cholestatic syndrome.  
The heterozygous carriers for Wilson disease occasionally 
have modest elevated values, but rarely higher than 
125 UG/G of dry weight.  In general, the liver copper content 
is higher than 250 UG/G dried tissue in Wilson disease patients.

250-1000 UG/G Dry Weight.......High.  This finding is suggestive
of possible Wilson disease.

>1000  UG/G Dry Weght........Very High.  Strongly suggestive
of Wilson disease.

Component Information

Collection Notes

Additional Comments

 

Questions or Comments email support@mgh.org

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