AMITRIPTYLINE AND NORTRIPTYLINE
Marquette General Health System

General Info

Alpha Code

   AMIT

MGH LIS Test No

   1334

Schedule

   Monday-Friday

Testing Time

   2-3 Days

Testing Lab

   Specialty Labs, Inc.

QORR Test Code

   AMIT

Specimen Info

Type

   Serum  

Volume

   2.0 (1.0) mL

Temperature

   Ambient, Refrigerated or Frozen

Preservative

    

Collection Info

   Serum separator tubes are not acceptable.  Collect at steady state trough concentration, 
at least 12 hours after last dose.
 
Specimen Acceptability

Methods
High Performance Liquid Chromatography

Clinical Utilities
The tricyclics are used to treat depression. Nortriptyline is a breakdown by-product of Amitriptyline. Elimination half-life is 9-46 hours and Nortriptyline is 18-93 hours.

CPT Codes
80152

Reference Range

Component Information

Name

   AMITRIPTYLINE 

Method

   HPLC 

CPT Code

   80152 

Units

    
Ref Range   N/A 
Reflex Reason    
     

Name

   NORTRIPTYLINE 

Method

   HPLC 

CPT Code

    

Units

    
Ref Range   50-150 ng/mL 
Reflex Reason    
     

Name

   AMITRIPTYLINE PLUS NORTRIPTYLINE 

Method

   HPLC 

CPT Code

    

Units

    
Ref Range   THERAPEUTIC RANGES for Amitriptyline + Nortriptyline, HPLC: 100 - 250 ng/mL 
Reflex Reason    
     
Collection Notes
Serum separator tubes are not acceptable; use polypropylene
tubes and ship on cold pack by overnight courier.

Additional Comments

 

Questions or Comments email support@mgh.org

Reference Lab Home Page
Laboratory Main Page
Marquette General Health System Home Page